The present Manchester Gregorians began in 1959, though an Old Gregorians Football Club played on and off for a number of years in the late ’40s and early ’50s.

In 1959, the club started as the Old Gregorians AFC, with one team playing in the Manchester Junior Catholic League. The club joined the Lancashire Amateur League in 1962, where it won many honours, including one season (I977/78) when all six teams won their respective divisions, as well as winning the League Aggregate Trophy for First and Reserve Teams, plus the League Trophy for the most points per game for all matches played by its teams.

After playing for many years in the Lancashire Amateur League, the club moved to the Manchester Football League in the 2005/06 season. Since its move the club has continued to be successful, with the First Team winning the Premier Division in 2008/09 and 2010/11. The First Team also won the Lancashire County FA Amateur Shield in the 2008/09 season and the Northern Counties FA Senior Cup, representing the Lancashire County FA, in 2009/10. The club’s ‘A’ Team won Division Three of the Manchester Football League in 2010/11.